Generally higher hit rates are observed in screening focused bioactive libraries when compared with the screening of diverse sets, and the hit clusters obtained from a successful focused library screening campaign usually exhibit discernable structure-activity relationships that facilitate follow up of these hits. Focused Bioactive Libraries is a powerful tool for drug screening, cell induction, drug repurposing, mechanism research, target identification, positive control and other related research fields.

General Bioactive Libraries：General Bioactive Libraries: Covering nearly 20,000 known biologically active small molecules, including Bioactive Compound Library, Approved Drug Library, Clinical Compound Library, FDA-Approved Drug Library, and Featured Novel Bioactive Compound Library.

Approved / Repurposing：There are five libraries in this category: Approved Drug Library, Clinical Compound Library, Drug Repurposing Library, FDA-Approved Drug Library, and Preclinical Compound Library. The purpose of such screening collections is to enable rapid testing of compounds with demonstrated safety profiles in new indications, such as neglected or rare diseases, where there is less commercial motivation for expensive research and development.

Disease Focused：These include focused libraries of small-molecule compounds with potential biological activity towards certain diseases (such as Anti-Cancer Compound Library, Anti-Diabetic Compound Library, Anti-Cardiovascular Disease Compound Library, etc.).

Target / Pathway Focused：A target-focused library is a screening collection of compounds specifically tailored to modulate the function of a particular target or a protein family. These libraries not only reduce waste by eliminating compounds that are unlikely to bind to target proteins, but often lead to the increased potency and specificity of binders, as demonstrated for c-Src kinase. Compared to large and diverse screening libraries, using relatively small and targeted collections significantly improves the odds of finding potential drug candidates, thus further reduces the costs of drug discovery.

Characteristic Bioactive Libraries：These include those focused libraries of small-molecule compounds with their specific applications (Antibiotics Library, CNS-Penetrant Compound Library, DNA Damage & Repair Compound Library, Neural Regeneration Compound Library, PPI Inhibitors Library, etc.).

Natural products are an unsurpassed source of chemical diversity and an ideal starting point for any screening program for pharmacologically active small molecules. Historically, natural products have been the most successful source of new drugs. Natural Product Libraries is a powerful tool for cell induction research and the drug screening focused on unique natural structures along with new bioactivity.

Natural Product Library for HTS：The TargetMol natural product libraries are continuously updated and contain structurally novel and active natural products from plants, animals, microorganisms and marine organisms. Our natural product libraries can be used for high-throughput screening, high-content screening, new drug development, pharmacological research and other fields, and are globally cited by highly-scored journals.

Characteristic Natural Product Libraries：Natural products originate from various sources, including animals, plants, microorganisms, etc. With their diverse structures, natural products cover over 30 types of unique compound structures, including flavonoids and alkaloids, and exhibit various biological activities such as anti-cancer and anti-inflammatory characteristics. Based on the number of genes, it has been estimated that the plant kingdom contains more than 200,000 different metabolites with values for single species ranging between 5,000 and 15,000, values that are significantly greater than those of microorganisms (∼1,500) and animals (∼2,500). We created several Characteristic Natural Product Libraries based on their biogenesis and the source they originate from (Alkaloid Natural Product Library, Flavonoid Natural Product Library, Polyphenolic Natural Product Library, Terpene Natural Product Library, Selected Plant-Sourced Compound Library, and Microbial Natural Product Library) as well as their specific applications (Anti-Inflammatory Traditional Chinese Medicine Compound Library, Anti-Tumor Natural Product Library, and Food as Medicine Compound Library). In addition, we can formulate customized natural product library for our customers with specific needs.

Natural Product Derivatives Libraries：Natural products have been a treasure trove for new drug development, a source of new structures and new ideas. Since the 1940s, nearly 75% of the newly discovered small molecule anti-cancer drugs are associated with natural products, and 40 natural product derivatives were approved between 1998 and 2009. Natural products and their derivatives are potent tools for studying and modulating protein function and natural product-related drug designs.

TCM Natural Product Library：Traditional Chinese medicine (TCM), with rich historical and cultural significance, are important components of ancient medical systemshas.TCM have rich clinical experience and application cases in clinic. For example, ginseng is considered one precious medicinal material in TCM and is widely used for increasing vital life force, enhancing immunity, and improving physical strength. Saffron is a traditional Tibetan medicine used to treat conditions such as depression, anxiety, and irregular menstruation. With the advancement of medical technology, some Chinese ethnic medicines have been integrated into the modern medical system and developed into drugs or health supplements. TargetMol provides a library of diverse compounds related to TCM, covering Mongolian medicine, Miao medicine, Yao medicine, Tibetan medicine, etc. These resources accelerate the research on TCM and promote their application in the field of medicine.

Structure-classified Natural Product Library：TargetMol offers a wide range of natural products encompassing various structures, including carbohydrates and glycosides, phenylpropanoids, quinones, flavonoids, terpenes, steroids, alkaloids, phenols, acids, and aldehydes. These natural products have extensive applications in medicine, biology, and chemistry research. To better meet customer needs, we have established a structure-classified natural product library, such as flavonoid natural product library, terpene natural product library, and alkaloid natural product library. These libraries are available for high-throughput screening and virtual screening to accelerate drug discovery and biological research.

Activity-classified Natural Product Library：Natural products possess a variety of biological activities such as anti-tumor, anti-inflammatory, and antioxidant properties. To better utilize these biological activities, TargetMol has categorized natural products based on their biological activities and form libraries for anti-infection, anti-parasitic, anti-cancer, anti-inflammatory, and antiviral purposes. These libraries contain known active compounds as well as related compounds with therapeutic potential, providing researchers with a wealth of resources to accelerate drug discovery and biological research processes.

Fragment-based drug discovery (FBDD) has emerged in the past decade as an alternative approach to traditional lead identification via high-throughput screening (HTS). Unlike HTS, FBDD identifies smaller compounds, the “fragments,” which bind to different parts of a biological target. FBDD has played a role in discovery of 2 approved drugs and at least 30 drugs that are in various stages of clinical development. In response to this evident trend in drug discovery, TargetMol has designed its Fragment Libraries, including a selection of unique fragment subsets: Drug-Fragment Library, High Solubility Fragment Library, and Featured Fragment Library.

This is a collection of up to 12 million small molecules, an effective tool for scientific research and new drug target screening. It is a high-quality choice for high-throughput screening (HTS), high-content screening (HCS), and virtual screening. There are currently 50 million compounds commercially available in the global market, from which we have selected products with reliable quality and good drug-like diversity to form highly cost-effective drug-like compound libraries, providing experimental samples for our customers. Drug-like compound libraries are TargetMol's core products with many operational cases and accumulated rich professional experience. If you would like to build your own customized HTS compound library, please feel free to contact our technical support.

Compound Libraries for HTS/HCS：High-throughput screening and high-content screening (HTS, HCS) are the current mainstream drug screening methods with the advantages of being microscopic, rapid, sensitive, and accurate, and can screen thousands of samples simultaneously. These techniques rely heavily on a large number of compound libraries designed with high structural diversity. And to cover various research fields, the diversity of potential targets must also be considered. There are about 50 million compounds commercially available in the global market, and we apply rigorous selection criteria to only select compounds with reliable quality and good drug-like diversities. During the design and screening process of our compound libraries, we use a series of methods to ensure the diversity and high specificity of our libraries. These libraries have been extensively validated by our in-house bioassays and by the laboratories of over 200 external partners, covering pharmaceutical, biotechnology, academic fields, and screening centers in the US, Europe, and Japan.

Targetmol compound libraries provide collections of variously compounds for drug repurposing, target validation, tool compound identification, and assay development in all research fields. We provide expertly selected chemical libraries of annotated bioactive compounds and novelty chemical synthesis compounds

Cardiovascular disease：Cardiovascular diseases refer to a group of conditions affecting the heart and blood vessel system, including coronary artery disease (leading to angina and myocardial infarction), hypertension, heart failure, cerebrovascular diseases, and others. These diseases are often closely associated with impaired vascular health, such as atherosclerosis, and lifestyle factors such as unhealthy diet, lack of exercise, smoking, and excessive drinking are also major contributors. Cardiovascular diseases are one of the leading health problems worldwide and are among the primary causes of death in adults. Prevention and treatment of cardiovascular diseases require not only lifestyle changes but also play a crucial role in pharmacotherapy and surgical interventions. Researchers are dedicated to deciphering the pathogenesis of cardiovascular diseases and developing and testing new drugs and treatment strategies to more effectively address the challenges posed by these diseases.

Digestive disorders：The digestive system made up of the gastrointestinal tract (GI), liver, pancreas, and gallbladder helps the body digest food. Digestion is important for breaking down food into nutrients, which your body uses for energy, growth, and cell repair.Some digestive diseases and conditions are acute, lasting only a short time, while others are chronic, or long-lasting.

Tumor/Cancer：Cancer is a serious disease caused by the unrestricted proliferation of cells in the body that lose normal growth control. It can occur in any part of the body, such as the lungs, breasts, colon, and skin. Cancer is one of the major threats to global health, causing millions of deaths each year and bringing profound pain and economic burdens to patients and their families. In recent years, there has been significant progress in the field of cancer treatment, especially in areas such as targeted therapy and immunotherapy. Researchers are working hard to discover new biomarkers and treatment methods to further improve treatment effectiveness.

Neurological disorders：Neurological disorders are diseases of the central and peripheral nervous system. In other words, the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscles. These disorders include epilepsy, Alzheimer disease and other dementias, cerebrovascular diseases including stroke, migraine and other headache disorders, multiple sclerosis, Parkinson's disease, neuroinfections, brain tumours, traumatic disorders of the nervous system due to head trauma, and neurological disorders as a result of malnutrition.

Metabolic diseases：Metabolic disorders are medical conditions that impact your metabolism, a wide array of processes that enable proper bodily functioning and balance. There are two main parts to metabolism:catabolism and anabolism. Catabolism is the process of breaking down carbohydrates, protein, and fat from food, which releases energy. Anabolism is the process that uses that energy to build, repair, and grow.

Inflammation and immunity：Immune and inflammatory diseases constitute a diverse and complex array of health problems, primarily involving abnormal reactions of the immune system. These diseases include autoimmune conditions such as rheumatoid arthritis and systemic lupus erythematosus, as well as conditions like asthma and allergic diseases, which are caused by the immune system's overreaction to environmental factors. The complexity of these diseases stems from their pathogenesis, involving a combination of genetic factors, environmental influences, and lifestyle choices. They pose not only a challenge to individual health but also place a significant burden on public health systems.

Development and reproduction：Molecular Reproduction and Development takes an integrated approach to understanding the dynamic field of cellular, reproductive, and developmental processes. Readers come to our journal to learn about current progress in the approaches that will be the groundwork for the next generation of research in reproductive and developmental biology.

Anti-infective：Infectious diseases are illnesses caused by various pathogens such as bacteria, viruses, fungi, or parasites, and they can be transmitted through various means including air, food, water, or direct human contact. Common infectious diseases include influenza, HIV/AIDS, tuberculosis, malaria, and novel coronavirus diseases. These diseases pose a serious threat to global public health.