Cytokine Inhibitor Library

Product No.： L3600

Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling, modulate the balance between humoral and cell-based immune responses, and are heavily involved in autoimmune and inflammatory diseases. Blocking cytokine signaling pathways by biologics has shown clinical effectiveness in these diseases.

Cytokines act through receptors and activate related signaling to modulate gene expression and cell functions. Cytokine receptors activate many signaling pathways: JAK-STAT, NF-kB, MAPK, PI3K, etc. A number of small molecular weight inhibitors targeting cytokine signaling have been identified as research progresses and some are approved to be marketed. Cytokines Inhibitors Library from TargetMol, containing 604 compounds targeting cytokine signaling, can be used for high throughput and high content screening for drug discovery.

Product No.：L3600

Product Description

A unique collection of 604 compounds targeting cytokine signaling for high throughput screening and high content screening for drug discovery;
Bioactivity and safety confirmed by pre-clinical research and clinical trials, and most of them are approved to be marketed;
Targets cover various cytokines including IL, CSF, IFN, TNF, TGF-beta family, growth factors, chemokine family, etc;
Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
Structurally diverse, medicinally active, and cell permeable;
NMR and HPLC validated to ensure high purity and quality;

Compound Service

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Compound library Consultation

Composition of compound library

EGFR (130)

VEGFR (129)

TNF (79)

Apoptosis (77)

PDGFR (76)

FGFR (72)

Autophagy (61)

IL Receptor (60)

c-Kit (54)

TGF-beta/Smad (48)

c-Met/HGFR (47)

FLT (43)

Src (32)

CXCR (31)

NF-κB (30)

CCR (29)

Interleukin (28)

IGF-1R (27)

ALK (26)

HER (25)

Others (23)

Bcr-Abl (21)

c-RET (19)

JAK (18)

COX (16)

c-Fms (16)

Endogenous Metabolite (15)

HIV Protease (14)

Raf (14)

Antibacterial (14)

TAM Receptor (13)

RIP kinase (12)

CSF-1R (11)

CDK (11)

Potassium Channel (11)

p38 MAPK (9)

Aurora Kinase (9)

IFNAR (8)

Tyrosine Kinases (8)

ERK (8)

STAT (8)

Parasite (7)

Drug Metabolite (7)

Trk receptor (7)

FAK (7)

BTK (6)

DNA/RNA Synthesis (6)

5-HT Receptor (6)

Tyrosinase (6)

NO Synthase (6)

Ferroptosis (5)

JNK (5)

Caspase (5)

PKC (5)

PDE (5)

Reactive Oxygen Species (5)

Akt (5)

IκB/IKK (5)

MEK (5)

PKA (4)

ROS (4)

MMP (4)

Chk (4)

TLR (4)

Ephrin Receptor (4)

Influenza Virus (4)

P450 (4)

NOD (4)

Sodium Channel (4)

S6 Kinase (4)

MLK (4)

NOS (3)

HCV Protease (3)

PI3K (3)

Tie-2 (3)

Mitophagy (3)

GSK-3 (3)

Virus Protease (3)

PPAR (3)

Calcium Channel (3)

Molecular Glues (3)

STING (3)

Ligand for E3 Ligase (3)

HDAC (3)

AMPK (3)

Discoidin Domain Receptor (DDR) (3)

Anti-infection (3)

ROS Kinase (3)

NOD-like Receptor (NLR) (3)

Chloride channel (2)

Antifungal (2)

Histamine Receptor (2)

Hck (2)

PYK2 (2)

Adrenergic Receptor (2)

IRE1 (2)

Mitochondrial Metabolism (2)

mTOR (2)

MAPK (2)

P-gp (2)

transporter (2)

Casein Kinase (2)

GABA Receptor (2)

Syk (2)

ATPase (1)

Proton pump (1)

ROR (1)

Integrin (1)

Estrogen/progestogen Receptor (1)

Dehydrogenase (1)

Antioxidant (1)

LTR (1)

Adenosine Receptor (1)

Na+/Ca2+ Exchanger (1)

Arrestin (1)

NADPH (1)

Lipase (1)

VDA (1)

Progesterone Receptor (1)

c-Myc (1)

MRP (1)

HBV (1)

Estrogen Receptor/ERR (1)

Wnt/beta-catenin (1)

PARP (1)

Serine Protease (1)

cell cycle arrest (1)

Leukotriene Receptor (1)

NAMPT (1)

Glucokinase (1)

TRP/TRPV Channel (1)

ROCK (1)

Amylase (1)

iGluR (1)

Glucocorticoid Receptor (1)

Topoisomerase (1)

Annexin A (1)

E1/E2/E3 Enzyme (1)

LDL (1)

Antifection (1)

BCL (1)

DNA Alkylation (1)

FAAH (1)

PAD (1)

ACK (1)

Lipoxygenase (1)

Epigenetic Reader Domain (1)

CaMK (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

PGE Synthase (1)

AChE (1)

MNK (1)

Antiviral (1)

Prostaglandin Receptor (1)

SARS-CoV (1)

LRRK2 (1)

Sirtuin (1)

Histone Acetyltransferase (1)

Nrf2 (1)

Beta Amyloid (1)

Reverse Transcriptase (1)

PDK (1)

Phospholipase (1)

PLK (1)

SGK (1)

AChR (1)

Gap Junction Protein (1)

NADPH-oxidase (1)

Microtubule Associated (1)

Antibiotic (1)

HIF/HIF Prolyl-Hydroxylase (1)

CFTR (1)

PKM (1)

Example of compound library information

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

Specification	Special Discount Waiting for you to inquire！
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