NF-κB Signaling Compound Library

Product No.： L3800

Nuclear factor-κB (NF-κB), a collective term for a family of transcription factors, includes five subunits: NF-κB1 (p50/p105), NF-κB2 (p52/p100), p65 (RelA), RelB, and c-Rel. The homodimers or heterodimers formed by two subunits bind to specific sequences known as the κB site on their target genes for DNA interaction and transcriptional activation. How NF-κB selectively recognizes a small subset of relevant κB sites from the large excess of potential binding sites is a critical step for stimulus-specific gene transcription (The fine-tuning of the NF-B DNA binding activity).While in an inactivated state, NF-κB is located in the cytosol complexed with the inhibitory protein IκBα. Through the intermediacy of integral membrane receptors, a variety of extracellular signals can activate the enzyme IκB kinase(IKK). IKK, in turn, phosphorylates the IκBα protein, which results in ubiquitination, dissociation of IκBα from NF-κB, and eventual degradation of IκBα by the proteasome. The activated NF-κB is then translocated into the nucleus where it binds to specific sequences of DNA called response elements (RE). The DNA/NF-κB complex then recruits other proteins such as coactivators and RNA polymerase, which transcribe downstream DNA into mRNA. A large array of genes involved in different processes of the immune and inflammatory responses, such as TNF-α, IL-1β, IL-6, and IL-8, chemokines, adhesion molecules, clone stimulating factors, is mediated by NF-κB. In TNF-α–induced apoptosis, TRAF1, TRAF2, XIAP, c-IAP1, and c-IAP2 were identified as gene targets of NF-kB transcriptional activity.

NF-κB Signaling Compound Library from TargetMol, a unique collection of 729 small molecules targeting NF-κB signaling, can be used for research in NF-κB signaling and high throughput screening and high content screening.

Product No.：L3800

Product Description

A unique collection of 729 compounds targeting NF-κB signaling for high throughput screening and high content screening;
Effective tool for research in NF-κB signaling and related drug screening;
Bioactivity and safety confirmed by pre-clinical research and clinical trials;
Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
Structurally diverse, medicinally active, and cell permeable;
NMR and HPLC validated to ensure high purity and quality;

Compound Service

Our compound library can be flexibly customized！View More

Compound library Consultation

Composition of compound library

Reactive Oxygen Species (159)

Apoptosis (138)

HDAC (105)

Autophagy (91)

TNF (82)

Others (67)

Endogenous Metabolite (62)

ROS (51)

Antibacterial (46)

Nrf2 (45)

COX (42)

IκB/IKK (40)

IL Receptor (34)

RIP kinase (27)

p38 MAPK (24)

ERK (24)

NOD (23)

Ferroptosis (20)

Antioxidant (20)

NO Synthase (20)

HIV Protease (19)

IRAK (18)

JNK (16)

Antifungal (15)

Influenza Virus (14)

STAT (14)

Akt (13)

NOD-like Receptor (NLR) (13)

Antibiotic (11)

ROS Kinase (11)

NOS (10)

Mitophagy (10)

P450 (10)

Caspase (9)

Calcium Channel (9)

Mitochondrial Metabolism (9)

PPAR (9)

Parasite (9)

Interleukin (9)

Virus Protease (8)

PDE (8)

MMP (8)

Lipoxygenase (8)

EGFR (8)

PI3K (7)

DNA/RNA Synthesis (7)

TLR (7)

ALK (7)

HIF/HIF Prolyl-Hydroxylase (7)

p53 (7)

Estrogen/progestogen Receptor (6)

Topoisomerase (6)

CDK (6)

JAK (6)

MAPK (6)

Beta Amyloid (6)

GABA Receptor (6)

Sodium Channel (6)

Tyrosinase (6)

Dehydrogenase (5)

Xanthine Oxidase (5)

AChE (5)

AMPK (5)

Potassium Channel (5)

AChR (5)

MALT (4)

c-Met/HGFR (4)

Proteasome (4)

Wnt/beta-catenin (4)

E1/E2/E3 Enzyme (4)

BCL (4)

Src (3)

NADPH (3)

Adenosine Receptor (3)

VEGFR (3)

TRP/TRPV Channel (3)

MAO (3)

PKC (3)

Gamma-secretase (3)

Antifection (3)

Opioid Receptor (3)

PGE Synthase (3)

HSP (3)

SARS-CoV (3)

Free radical scavengers (3)

Sirtuin (3)

transporter (3)

IGF-1R (3)

Prostaglandin Receptor (3)

Trk receptor (3)

5-HT Receptor (3)

MEK (3)

FGFR (3)

FLT (3)

Ligand for E3 Ligase (3)

HIF (3)

Anti-infection (3)

S6 Kinase (3)

HER (3)

Chloride channel (2)

RAAS (2)

Histamine Receptor (2)

Glutathione Peroxidase (2)

ATPase (2)

Transferase (2)

LTR (2)

IFNAR (2)

PKA (2)

Estrogen Receptor/ERR (2)

RANKL/RANK (2)

Bcr-Abl (2)

Tyrosine Kinases (2)

Leukotriene Receptor (2)

Immunology/Inflammation related (2)

Drug Metabolite (2)

HSV (2)

GluR (2)

CaMK (2)

TGF-beta/Smad (2)

P-gp (2)

STING (2)

Molecular Glues (2)

mTOR (2)

Antiviral (2)

GST (2)

PDK (2)

Casein Kinase (2)

Reverse Transcriptase (2)

Retinoid Receptor (2)

Cannabinoid Receptor (2)

Syk (2)

Microtubule Associated (2)

FAK (2)

Carbonic Anhydrase (1)

ROR (1)

HCV Protease (1)

Reductase (1)

BACE (1)

RAR/RXR (1)

GSK-3 (1)

c-Myc (1)

Mdm2 (1)

NPC1L1 (1)

Integrin (1)

Necroptosis (1)

OCT (1)

PARP (1)

Serine Protease (1)

Serine/threonin kinase (1)

Adrenergic Receptor (1)

Amylase (1)

iGluR (1)

IAP (1)

Glucocorticoid Receptor (1)

LDL (1)

HBV (1)

Cysteine Protease (1)

Liver X Receptor (1)

Aryl Hydrocarbon Receptor (1)

Haspin Kinase (1)

Glucosidase (1)

BTK (1)

Somatostatin (1)

Chk (1)

Aurora Kinase (1)

cAMP (1)

Epigenetic Reader Domain (1)

DUB (1)

OXPHOS (1)

Glutathione reductase (1)

LRRK2 (1)

cGAS (1)

PAK (1)

PDGFR (1)

Hedgehog/Smoothened (1)

CCR (1)

PTEN (1)

PAD (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

SGLT (1)

Aminopeptidase (1)

Histone Acetyltransferase (1)

ATM/ATR (1)

CFTR (1)

MLK (1)

PKM (1)

RSV (1)

Aromatase (1)

Phospholipase (1)

PLK (1)

Adenosine deaminase (1)

Complement System (1)

Discoidin Domain Receptor (DDR) (1)

Platelet aggregation (1)

c-Kit (1)

NADPH-oxidase (1)

DNA Methyltransferase (1)

Monoamine Oxidase (1)

S1P Receptor (1)

Example of compound library information

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

Specification	Special Discount Waiting for you to inquire！
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