Natural products have been proven to demonstrate their success in modulating certain isolated but important targets, such as a range of antimicrobial targets, in particular protein-protein interactions. Therefore, many researchers consider natural products and their derivatives as unique tools for the study and manipulation of protein function.

Covalent compounds, a class of organic small molecules, can interact with specific target proteins and form covalent bonds, resulting in a change in protein conformation that inhibits protein activity. Except for some rare cases, protein modifications by covalent interactions are usually irreversible.

TargetMol Natural Product Covalent Library carefully screens 583 covalent compounds of natural products, which have not only the characteristics of natural products but also the mechanism of action of covalent compounds, and are cost-effective and powerful tools for drug development, pharmacological studies, stem cell differentiation, fingerprinting studies, quality studies and other fields.