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jak_stat_compound_library
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JAK-STAT Compound Library
Product No.: L3700

Cell signal transduction is the transmission of molecular signals via various proteins in a signaling cascade, which carries and amplifies the signal. The JAK-STAT signaling pathway communicates information from chemical signals outside of a cell to the cell nucleus, resulting in the activation of genes through a process called transcription. There are three key parts of JAK-STAT signaling: Janus kinases (JAKs), Signal Transducer and Activator of Transcription proteins (STATs), and receptors (which bind the chemical signals). JAK-STAT signaling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumor formation. Disrupted JAK-STAT signaling may lead to a variety of diseases, such as skin conditions, cancers, and disorders affecting the immune system. There are 4 JAK proteins: JAK1, JAK2, JAK3 and TYK2, and there are 7 STAT proteins: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6.

JAK/STAT Compound Library from TargetMol, a unique collection of 252 compounds targeting JAK/STAT signaling, can be used for research in JAK/STAT signaling and related drug screening (high throughput and high content screening).

Product No.:L3700
  • A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;
  • Effective tool for studying the JAK/STAT targets;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;
Compound Service
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Compound library Consultation
Composition of compound library
EGFR (97)
JAK (80)
STAT (71)
Apoptosis (60)
Autophagy (32)
HER (24)
Tyrosine Kinases (20)
FLT (13)
Src (12)
VEGFR (12)
Pim (9)
CDK (9)
PDGFR (9)
NF-κB (9)
FGFR (9)
Potassium Channel (9)
Antibacterial (8)
Parasite (7)
Others (6)
Endogenous Metabolite (6)
Antibiotic (5)
HIV Protease (4)
p38 MAPK (4)
Bcr-Abl (4)
IL Receptor (4)
Somatostatin (4)
IκB/IKK (4)
c-RET (4)
Histone Methyltransferase (3)
Ferroptosis (3)
ERK (3)
BTK (3)
IGF-1R (3)
COX (3)
Interleukin (3)
Influenza Virus (3)
AMPK (3)
Syk (3)
c-Kit (3)
HCV Protease (2)
IFNAR (2)
Mitophagy (2)
Virus Protease (2)
Estrogen Receptor/ERR (2)
Caspase (2)
PKC (2)
Reactive Oxygen Species (2)
Aurora Kinase (2)
Akt (2)
TLR (2)
Beta Amyloid (2)
5-HT Receptor (2)
MEK (2)
TNF (2)
Sodium Channel (2)
NOS (1)
Dopamine Receptor (1)
Integrin (1)
Estrogen/progestogen Receptor (1)
Antifungal (1)
PI3K (1)
Antioxidant (1)
Na+/Ca2+ Exchanger (1)
Histamine Receptor (1)
JNK (1)
Phosphatase (1)
GSK-3 (1)
PKA (1)
HBV (1)
Wnt/beta-catenin (1)
Cysteine Protease (1)
Nucleoside Antimetabolite/Analog (1)
Calcium Channel (1)
ROCK (1)
Adrenergic Receptor (1)
Topoisomerase (1)
UGT (1)
PDE (1)
Raf (1)
Drug Metabolite (1)
ROS (1)
BCL (1)
FAAH (1)
CXCR (1)
PTEN (1)
Chk (1)
MMP (1)
cAMP (1)
TGF-beta/Smad (1)
DNA/RNA Synthesis (1)
Survivin (1)
P-gp (1)
HSP (1)
Trk receptor (1)
Histone Acetyltransferase (1)
Nrf2 (1)
hCE (1)
ALK (1)
Casein Kinase (1)
Hippo pathway (1)
Reverse Transcriptase (1)
HDAC (1)
c-Fms (1)
P450 (1)
HIF (1)
PLK (1)
AChR (1)
Anti-infection (1)
NADPH-oxidase (1)
Ras (1)
cholecystokinin (1)
HIF/HIF Prolyl-Hydroxylase (1)
FAK (1)
PD-1/PD-L1 (1)
NO Synthase (1)
Monoamine Oxidase (1)
Example of compound library information
Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE