Nucleoside analogues are nucleosides which contain a nucleic acid analogue and a sugar. Nucleotide analogs are nucleotides which contain a nucleic acid analogue, a sugar, and one to three phosphate groups. Nucleoside and nucleotide analogues can be used in therapeutic drugs, include a range of antiviral products used to prevent viral replication in infected cells. These agents can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Among the current anti-viral drugs, almost 50% are nucleoside or nucleotide analogues. Anti-tumor drugs such as Cytarabine and Doxifluridine are also nucleotide analogues. The recently developed nucleoside analogues include HIV reverse transcriptase inhibitors Zidovudine, Didanosine, Zalcitabine, Stavudine, Lamivudine; Vidarabine, an antiviral drug which is active against herpes simplex and varicella zoster viruses; Acyclovir and Famciclovir, used for the treatment of herpes simplex virus infections; Ribavirin, also known as tribavirin, is an antiviral medication used to treat RSV infection, hepatitis C and some viral hemorrhagic fevers.

TargetMol ‘s nucleotide compound library collects 334 nucleoside and nucleotide analogues, some of which are in the clinical trial phases or marketed therapeutic drugs, can be used for research and development of anti-viral, anti-tumor, anti-fungal, and anti-depressive drugs.