Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, and is genetically, biochemically and morphologically distinct from other forms of regulated cell death such as apoptosis, necroptosis, and autophagic cell death. It is characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, hepatic and heart ischemia/reperfusion injury, and T-cell immunity. Understanding the molecular mechanisms and signaling pathways of ferroptosis may provide new diagnostic and therapeutic approaches to regulate cell survival and death in human disease.

TargetMol collects 779 compounds related to ferroptosis signaling pathway with targets including GPX4, System Xc−, HSPB1, NRF2, VDAC2/3, Ras, TFR1, NOX, p53, CARS, ROS, SLC7A11, etc. Iron chelators and lipid peroxidation inhibitors are also included in this library.