Coagulation is the process by which blood changes from a liquid to a gel, forming a blood clot. Substances that take part in the coagulation cascade are called clotting factors. The blood clotting process is complex and mainly involves three steps: producing prothrombin activator, prothrombin being converted to thrombin, and fibrinogen being converted to fibrin. Anticlotting mechanisms are important in restricting clot formation to the site of injury. The two major systems are the anticoagulant and fibrinolytic systems. The balance of coagulation and anticlotting mechanism keeps the hemostatic system functioning efficiently. It is currently believed that the anticoagulant mechanism mainly has the barrier function of vascular endothelium, fibrin adsorption, phagocytosis of mononuclear macrophage system and physiological anticoagulant substances.

The TargetMol’s Procoagulants and Anticoagulants Library, a unique collection of 144 procoagulation and anticoagulation related compounds, can be used for research in coagulation and anticoagulation mechanisms, and related drug development.