Cardiovascular disease generally refers to all types of diseases that affect the heart or blood vessels, including coronary heart disease (clogged arteries), which can cause heart attacks, stroke, congenital heart defects and peripheral artery disease, and is the leading cause of death for men and women in the U.S. Different types of cardiovascular diseases have different mechanisms of pathogenesis. Antioxidants, lipid-lowering agents, anti-ischemic drugs, and platelet aggregation inhibitors all can reduce cardiovascular disease risk. Some natural products can inhibit the gene expression of cell adhesion molecules, cytokine, and chemokine, inhibit the function of platelet, enhance the release of nitric oxide by endothelial cells, and inhibit the contraction of smooth muscle.

A unique collection of 1408 cardiovascular diseases related compounds by TargetMol can be used for cardiovascular diseases related research and high throughput and high content screening for new drugs.