Inflammation is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators. The classical characteristics of inflammation are pain, swelling, edema, redness and heat. Anti-inflammatory drugs are the second most commonly clinically used drugs. The widely used anti-inflammatory drugs include non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids. However, both have a wide range of side effects. As research advanced, various natural products from traditional Chinese medicine (TCM) have been demonstrated in many animal or cell culture models to safely suppress proinflammatory pathways and control inflammation-associated disease. Plant chemical constituents are one of the richest hot spots for most significant new drug discoveries. Herbal medicines have gained special interest in recent years as a subject of both commercial and scientific interests.

TargetMol collects 1279 TCM monomers with anti-inflammatory activity in this library, including Flavone, Saponins, Terpenes, Alkaloids, etc. derived from herbs such as honeysuckle, Coptis chinensis, Baical Skullcap Root, Panax notoginseng, etc. With its diversity of compound structures and detailed information about bioactivity, it is a powerful tool for research in anti-inflammation.