Natural products are an unsurpassed source of chemical diversity and an ideal starting point for any screening program for pharmacologically active small molecules. Historically, natural products have been the most successful source of new drugs. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Natural products have been proven to be successful modulators of difficult targets such as a range of antibacterial targets and, especially, protein–protein interactions. Furthermore, many researchers consider natural products and their derivatives as a privileged tools for the study and manipulation of protein function.

The TargetMol’s Rare Natural Product Library, a unique collection of 693 rare natural products with known bioactivity and wide source, is a powerful tool for drug discovery, pharmacological study, and stem cell differentiation, etc.