Natural products have the advantage of diverse chemical structures and biological activities, making them irreplaceably important in the development of new drugs. The rapid development of extraction and structure identification techniques in recent years has greatly improved the efficiency and success rate of developing new drugs from natural products. According to statistics, nearly 2/3 of all drugs marketed between 1981 and 2019 are to some extent related to natural products. However, one of the problems that have long hindered the development of natural product drug screening is that usually when a natural product was identified as a hit, subsequent pharmacological experiments became difficult to proceed due to the general high cost of natural products. To avoid such a problem, TargetMol designed the L6010 Natural Product Library, which collects 3840 most cost-effective natural product monomers from a wide range of 1,800 plant sources with a high potential for drug discovery. We ensured that the follow-up cost of each monomer in bulk remains affordable, which helps to improve the efficiency of drug discovery by time shortening, costs reduction, and lead compound attainment with desirable effects.