CNS-Penetrant Compound Library

Product No.： L5900

The blood–brain barrier (BBB) is a highly selective semipermeable border that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS). In its neuroprotective role, the blood–brain barrier functions to hinder the delivery of many potentially important diagnostic and therapeutic agents to the brain. Overcoming the difficulty of delivering therapeutic agents to specific regions of the brain presents a major challenge to treatment of most brain disorders. Choosing the compounds that could penetrate BBB into the compound library targeting CNS is critical for CNS drug discovery. Based on the scientific literature, TargetMol collects 509 out of 5000 compounds as CNS-Penetrant Compound Library, which can be used for CNS-Penetrant related research and drug screening for CNS diseases.

Product No.：L5900

Product Description

A unique collection of 509 CNS-Penetrant compounds for high throughput screening (HTS) and high content screening (HCS);
Targets include Kinases, GPCR, and ion channels, etc.;
Effective tool for drug screening in brain disorders, such as brain tumor, mental disorders, and neurodegenerative diseases, etc.;
Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
Structurally diverse, medicinally active, and cell permeable and CNS penetrant;
NMR and HPLC/LCMS validated to ensure high purity and quality;

Compound Service

Our compound library can be flexibly customized！View More

Compound library Consultation

Composition of compound library

Autophagy (107)

Apoptosis (86)

5-HT Receptor (53)

Dopamine Receptor (40)

Others (40)

Antibacterial (40)

Antibiotic (37)

AChR (32)

Endogenous Metabolite (31)

HIV Protease (27)

Adrenergic Receptor (25)

COX (23)

Sodium Channel (23)

Histamine Receptor (22)

Mitophagy (18)

GABA Receptor (18)

Calcium Channel (16)

Serotonin Transporter (14)

EGFR (14)

DNA/RNA Synthesis (14)

iGluR (12)

Potassium Channel (12)

PI3K (11)

VEGFR (11)

Norepinephrine (11)

Reverse Transcriptase (11)

NF-κB (11)

c-Kit (11)

Ferroptosis (10)

Antifungal (10)

Parasite (10)

HDAC (10)

CDK (9)

Reactive Oxygen Species (9)

PDGFR (9)

GluR (9)

AChE (9)

mTOR (8)

Influenza Virus (8)

FLT (8)

Estrogen/progestogen Receptor (7)

Dehydrogenase (7)

Bcr-Abl (7)

Beta Amyloid (7)

MEK (7)

DNA Alkylator/Crosslinker (6)

Virus Protease (6)

Nucleoside Antimetabolite/Analog (6)

TRP/TRPV Channel (6)

Topoisomerase (6)

PDE (6)

Raf (6)

NMDAR (6)

Antifection (6)

P-gp (6)

SARS-CoV (6)

c-Fms (6)

Monoamine Oxidase (6)

Src (5)

LPL Receptor (5)

Adenosine Receptor (5)

MAO (5)

CSF-1R (5)

Glucocorticoid Receptor (5)

P450 (5)

TNF (5)

Microtubule Associated (5)

NOD-like Receptor (NLR) (5)

S1P Receptor (5)

Transferase (4)

p38 MAPK (4)

Estrogen Receptor/ERR (4)

Antifolate (4)

ERK (4)

Drug Metabolite (4)

DNA Alkylation (4)

HSV (4)

MMP (4)

LRRK2 (4)

FGFR (4)

Proton pump (3)

Carbonic Anhydrase (3)

HCV Protease (3)

ABC (3)

Tyrosine Kinases (3)

PPAR (3)

PARP (3)

Molecular Glues (3)

Opioid Receptor (3)

IL Receptor (3)

Epigenetic Reader Domain (3)

CaMK (3)

Interleukin (3)

TGF-beta/Smad (3)

ALK (3)

ATM/ATR (3)

Ligand for E3 Ligase (3)

Phospholipase (3)

Neurokinin receptor (3)

Proteasome (2)

advanced glycation end products (2)

NOS (2)

CAT (2)

DHFR (2)

ROR (2)

Histone Methyltransferase (2)

DNA-PK (2)

Ligands for Target Protein for PROTAC (2)

RAAS (2)

Phosphatase (2)

Progesterone Receptor (2)

Melatonin Receptor (2)

MRP (2)

HBV (2)

ROCK (2)

Aryl Hydrocarbon Receptor (2)

RIP kinase (2)

Gamma-secretase (2)

Mitochondrial Metabolism (2)

BTK (2)

Monoamine Transporter (2)

Isocitrate Dehydrogenase (IDH) (2)

BCL (2)

PAK (2)

Hedgehog/Smoothened (2)

FAAH (2)

Vasopressin Receptor (2)

OX Receptor (2)

Akt (2)

HSP (2)

Prostaglandin Receptor (2)

Trk receptor (2)

Sirtuin (2)

Decarboxylase (2)

IκB/IKK (2)

Retinoid Receptor (2)

STAT (2)

CRISPR/Cas9 (2)

GPR (2)

AMPK (2)

NOD (2)

HMG-CoA Reductase (2)

S6 Kinase (2)

HIF/HIF Prolyl-Hydroxylase (2)

CFTR (2)

PD-1/PD-L1 (2)

Mdm2 (1)

Hydrogenase (1)

Integrin (1)

c-Met/HGFR (1)

Antioxidant (1)

BACE (1)

Arrestin (1)

NADPH (1)

Histone Demethylase (1)

Lipase (1)

JNK (1)

Glutathione Peroxidase (1)

GSK-3 (1)

Wnt/beta-catenin (1)

Cysteine Protease (1)

Liver X Receptor (1)

Caspase (1)

PKC (1)

IRE1 (1)

Annexin A (1)

E1/E2/E3 Enzyme (1)

LDL (1)

MT Receptor (1)

P2X Receptor (1)

GlyT (1)

ROS (1)

Fatty Acid Synthase (1)

JAK (1)

CCR (1)

Chk (1)

Epoxide Hydrolase (1)

Aurora Kinase (1)

Lipoxygenase (1)

IGF-1R (1)

DUB (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Telomerase (1)

Lipid (1)

BCRP (1)

Beta-Secretase (1)

MAPK (1)

Antiviral (1)

Free radical scavengers (1)

Histone Acetyltransferase (1)

Nrf2 (1)

Pyroptosis (1)

RSV (1)

GST (1)

Aromatase (1)

PDK (1)

Hydroxylase (1)

Adenosine deaminase (1)

HIF (1)

SGK (1)

Complement System (1)

Cannabinoid Receptor (1)

Syk (1)

DNA Methyltransferase (1)

Ras (1)

Sigma receptor (1)

Tyrosinase (1)

AhR (1)

MLK (1)

Example of compound library information

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

Specification	Special Discount Waiting for you to inquire！
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