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Screening of Enzymatic Target Activity

Sample Delivery
Customers only need to provide compounds of the target to be tested, each 2-3mg, we will arrange the corresponding screening and testing services, and finally provide professional detection and analysis reports.
Inquiry and Order
Thank you for choosing our in vitro screening and analysis services for anti-tumor drugs. If you have any relevant questions, please contact our staff, we will answer and serve you immediately.
Screening of enzymatic target activity

Enzyme research has always been an important part of drug development. The drug screen has rich experience in enzyme screening, such as kinase profile screening, etc. The enzyme experiments cover more than 300 screening models, including common histone deacetylases, histone demethylases, tyrosine kinases, serine kinases, methyltransferases, phosphodiesterases, DNA repair enzymes, heat shock proteins, immune-related proteins, etc.

 

Flexible program scheduling, depending on the number of compounds, is available in both 96-well and 384-well plate screening modes to accelerate your drug development process.

Enzymatic Target Screening Model

Enzyme Target
Kinase ABL1s,ACK,AKTs,AMPKs,Auroras,etc. ADP-Glo
Bromodomains ATADs,BAZ2B,BPTF/FALZ,etc. TR-FRET/AlphaScreen
Deacetylases HDAC1/2/3/4/5/6/7/8/9,SIRT1/2/3/5,etc. Fluorogenic
Demethylases FBXL10/11,JARID1A/B/C/D,JMJD1A,etc. AlphaScreen/Chemiluminescent
Heat shock protein HSP90α,HSP90β,etc. AlphaScreen
Immnotherapy related ARG,CD,CTLA4,GITRL,IDO,etc. Colorimetric/Fluorogenic
Methyl-lysine CBX1,L3MBTL1,etc. AlphaScreen/Fluorogenic
Methyltransferases DNMTs,DOT1L,EHMT1/GLP,EZHs,etc Chemiluminescence
PARPs PARP1/2/3/6/7/10/11/14/15,TNKS1/S2,etc. Chemiluminescence/Colorimetric
Phosphodiesterase PDEs,Autotaxin,etc. TR-FRET/FP/Fluorogenic
Protease DPP3/4/7/8/9,FAP,POP,Renin,etc. Fluorogenic
Others COX,Myeloperoxidase,FAAH,FABP4,etc. FP/colorimetric/Fluorogenic

Main Detection Method

Biochemical detection analysis: ADP-Glo detection, Fluorescence detection, Absorbance light absorption detection, TR-FRET (resonance energy transfer) detection of substrate phosphorylation level, chemiluminescence detection, etc

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Basic Information
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Note: The exact values need to be tested, and the predicted values are predicted
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